Reduktion cyclischer Maleinsäurederivate Reduction of Cyclic Maleic Acid Derivatives
نویسندگان
چکیده
Z. Naturforsch. 51 b, 409-416 (1996); eingegangen am 28. Juni 1995 Reduction, Narthigenine, Butyrolactones, Butyrolactams, Tetramic Acids A series of potentially cytotoxic a,/?-unsaturated 7 -hydroxy-butyrolactones, -lactams and -thiolactones has been synthesized via regioselective hydride reduction of the appropriate maleic acid anhydrides, imides and thioanhydrides. By this means a straightforward access to naturally occurring antibiotic narthigenine 2, its hitherto unknown thio-analogue 5b and higher substituted derivatives and analogues of 2 is presented.
منابع مشابه
An expeditious synthesis of imides from phthalic, maleic and succinic anhydrides and chemoselective C=C reduction of maleic amide esters
Phthalic, maleic and succinic anhydrides have been reacted with aromatic amines to obtain the corresponding monoacid monoamides. The latter have been each transformed into the corresponding cyclic imide derivatives by treating with SOCl2. Alternatively, anhydrides have been reacted with methanolic KOH to obtain monomethyl ester derivatives which on reaction with aromatic amines in the presence ...
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